105'5 Spreeradio offers a variety of programs including "Jochen Trus am Morgen," "Der Vormittag mit Katja Desens," and "Der Nachmittag mit Claudia Campus." The station features "Song-Duell," "Flashback," and "Verbraucher Deckt auf," along with news, tips, and event information. Listeners can enjoy different music channels, podcasts, and reports on topics like organ donation and dopamine detox.