105'5 Spreeradio offers a variety of programs including "Jochen Trus am Morgen," "Der Vormittag mit Katja Desens," and "Der Nachmittag mit Claudia Campus." The station features segments like "Song-Duell," "Flashback," and "Verbraucher Deckt auf," alongside news, tips, and event information. Listeners can also enjoy various music channels and audio content, with a focus on songs from the 80s to the present.