Radio San Paolo della Croce began in 1986 as "Radio Missione" in Castellazzo Bormida. In 1990, it was re-established as Radio San Paolo della Croce with the support of local enthusiasts and the purchase of Radio Life's assets. The station's programming is primarily religious, with additional segments on local news, history, specific local services, and sports events. During hours when its own programming is not airing, it connects with Radio In Blu.