Program stanice je určen posluchačům za hranicemi České republiky a krajanům. Vysílání v češtině, angličtině, němčině, francouzštině, španělštině a ruštině, půlhodinová vysílání obsahují zpravodajství a publicistiku z ČR
Radio Prague International offers news from the Czech Republic, covering domestic and foreign policy, the European Union, economy, society, and culture. It features stories on Czech history, science, nature, and the Czech language, including a series on libraries and exhibitions. The station also highlights Czechs living abroad and their experiences, as well as cultural events and historical anniversaries within the Czech Republic.